Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 9/20 | 0.66 |
| ▸ | BPTF | Q12830 | 3/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38652202 | 0.86 | KRAS (0.75) | KRASBPTFSOS1ALDH1A1GAA | |
| SCHEMBL24091435 | 0.81 | KRAS (0.70) | KRASBPTFSOS1ALDH1A1GAA | |
| SCHEMBL31328651 | 0.80 | KRAS (1.00) | KRASBPTFSOS1ALDH1A1GAA | |
| SCHEMBL24091440 | 0.80 | KRAS (1.00) | KRASBPTFSOS1ALDH1A1GAA | |
| SCHEMBL24091569 | 0.80 | KRAS (1.00) | KRASBPTFSOS1ALDH1A1GAA | |
| SCHEMBL24091348 | 0.74 | KRAS (0.59) | KRASBPTFALDH1A1GAAHSD17B10 | |
| SCHEMBL24091446 | 0.72 | KRAS (0.85) | KRASBPTFSOS1ALDH1A1GAA | |
| SCHEMBL24091565 | 0.72 | KRAS (0.85) | KRASBPTFSOS1ALDH1A1GAA | |
| SCHEMBL24785070 | 0.71 | KRAS (1.00) | KRASBPTFSOS1ALDH1A1GAA | |
| SCHEMBL31328692 | 0.70 | KRAS (0.67) | KRASBPTFSOS1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025040767-A1 | 2-(3,8-DIAZABICYCLO[3.2.1]OCTAN-3-YL)-1,3,5-TRIAZINE DERIVATIVES AS KRAS G12D INHIBITORS FOR THE TREATMENT OF CANCER | SANOFI (FR) | 2025-02-27 | — | — | WO | disclosed |