Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 4/20 | 0.48 |
| ▸ | ALDH1A2 | O94788 | 3/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31329494 | 1.00 | MAP4K1 (0.51) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL21646064 | 1.00 | MAP4K1 (0.51) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL23674722 | 0.93 | CRBN (0.49) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL30100726 | 0.93 | CRBN (0.49) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL26441332 | 0.92 | TRPV1 (0.45) | MAP4K1CRBNCYP11B1CYP11B2ROCK2 | |
| SCHEMBL30345347 | 0.90 | CRBN (0.48) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL26441905 | 0.90 | CRBN (0.48) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL26088205 | 0.90 | CRBN (0.48) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL30100710 | 0.90 | CRBN (0.48) | MAP4K1CRBNHDAC3HDAC4HDAC1 | |
| SCHEMBL21687088 | 0.88 | CRBN (0.40) | MAP4K1CRBNHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112638881-B | Tetrahydroquinoline derivatives for the treatment of metastatic and chemotherapy-resistant cancers | 普林斯顿大学托管委员会 | 2025-01-07 | — | — | CN | disclosed |