Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22479310 | 0.87 | SLC18A3 (0.45) | SLC18A3SIGMAR1BRD4PIK3CADRD2 | |
| SCHEMBL1822246 | 0.85 | SLC18A3 (0.42) | SLC18A3SIGMAR1NOTUMBRD4PIK3CA | |
| SCHEMBL22471588 | 0.85 | PIK3CA (0.45) | SLC18A3SIGMAR1NOTUMBRD4PIK3CA | |
| SCHEMBL1823222 | 0.80 | SLC18A3 (0.38) | SLC18A3SIGMAR1BRD4BACE1MEN1 | |
| SCHEMBL1820468 | 0.80 | SLC18A3 (0.38) | SLC18A3SIGMAR1BRD4BACE1MEN1 | |
| SCHEMBL17771680 | 0.79 | BRD4 (0.37) | SLC18A3SIGMAR1NOTUMBRD4GABRA1 | |
| SCHEMBL30336432 | 0.79 | BRD4 (0.37) | SLC18A3SIGMAR1NOTUMBRD4GABRA1 | |
| SCHEMBL30954694 | 0.79 | NOTUM (0.46) | SLC18A3SIGMAR1NOTUMBRD4BACE1 | |
| SCHEMBL29076740 | 0.79 | NOTUM (0.46) | SLC18A3SIGMAR1NOTUMBRD4BACE1 | |
| SCHEMBL31330416 | 0.79 | NOTUM (0.43) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747242-A1 | HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE | Horizon Therapeutics Ireland Dac (IE) | 2026-05-27 | — | — | EP | disclosed |
| WO-2025019715-A1 | HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE | HORIZON THERAPEUTICS IRELAND DAC (IE) | 2025-01-23 | — | — | WO | disclosed |