Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 6/20 | 0.34 |
| ▸ | DRD5 | P21918 | 6/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31330708 | 0.97 | ADORA2A (0.40) | ADORA2AADORA2BTLR7PARGDRD1 | |
| SCHEMBL31330633 | 0.95 | PARG (0.38) | ADORA2AADORA2BTLR7PARGDRD1 | |
| SCHEMBL25359271 | 0.78 | ADORA2A (0.38) | ADORA2AADORA2BTLR7PARGDRD1 | |
| SCHEMBL31278641 | 0.76 | EGFR (0.40) | PARGMEN1LMNAKMT2A | |
| SCHEMBL26988300 | 0.76 | EGFR (0.40) | PARGMEN1LMNAKMT2A | |
| SCHEMBL25359931 | 0.75 | ADORA2A (0.41) | ADORA2AADORA2BTLR7PARGDRD1 | |
| SCHEMBL25361704 | 0.74 | ADORA2A (0.42) | ADORA2AADORA2BTLR7PARGDRD1 | |
| SCHEMBL31330681 | 0.74 | — | — | |
| SCHEMBL31330465 | 0.74 | GAA (0.46) | MEN1CRHBPKMT2ACRHR2 | |
| SCHEMBL31330832 | 0.73 | KDM4E (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4720061-A1 | TREM2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024246018-A1 | TREM2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-12-05 | — | — | WO | disclosed |