SCHEMBL31332467

SCHEMBL31332467

CN(C)[C@@H]1CCN(C(=O)c2cc3c(Cl)c(Cl)ccc3[nH]2)C1

nearest known ligand 0.63

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 5/20 0.63
JAK2 O60674 1/20 0.51
JAK1 P23458 1/20 0.51
TYK2 P29597 1/20 0.51
JAK3 P52333 1/20 0.51
TLR9 Q9NR96 4/20 0.44
TLR8 Q9NR97 4/20 0.44
TLR7 Q9NYK1 4/20 0.44
RORC P51449 2/20 0.44
MALT1 Q9UDY8 1/20 0.43
L3MBTL3 Q96JM7 1/20 0.41
PDK2 Q15119 1/20 0.40
SYK P43405 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31332548 0.85 HRH4 (0.60) HRH4
SCHEMBL31416347 0.85 HRH4 (0.60) HRH4PDK2
SCHEMBL31416220 0.85 HRH4 (0.60) HRH4PDK2
SCHEMBL31332457 0.83 HRH4 (0.63) HRH4
SCHEMBL31332439 0.82 HRH4 (0.63) HRH4PDK2
SCHEMBL31416332 0.82 HRH4 (0.62) HRH4
SCHEMBL4324479 0.81 HRH4 (0.62) HRH4
SCHEMBL31416301 0.81 HRH4 (0.61) HRH4PDK2
SCHEMBL31416148 0.81 HRH4 (0.61) HRH4PDK2
SCHEMBL31416402 0.81 HRH4 (0.61) HRH4PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747235-A1 KV1.3 POTASSIUM CHANNEL ANTAGONISTS Muna Therapeutics ApS (DK) 2026-05-27 EP claimed
WO-2025017105-A1 KV1.3 POTASSIUM CHANNEL ANTAGONISTS MUNA THERAPEUTICS APS (DK) 2025-01-23 WO claimed
EP-4747235-A1 KV1.3 POTASSIUM CHANNEL ANTAGONISTS Muna Therapeutics ApS (DK) 2026-05-27 EP disclosed
WO-2025017105-A1 KV1.3 POTASSIUM CHANNEL ANTAGONISTS MUNA THERAPEUTICS APS (DK) 2025-01-23 WO disclosed