SCHEMBL31334044

SCHEMBL31334044

O=C1CCC(Nc2ccc(N3CCN([C@H]4CC[C@H](C(=O)N[C@H]5CC[C@H](Nc6ncc(F)c(-c7cccc(-n8ccccc8=O)c7)n6)CC5)CC4)CC3)c(F)c2)C(=O)N1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.35
MAPT P10636 1/20 0.35
KMT2A Q03164 1/20 0.35
DDB1 Q16531 3/20 0.34
CRBN Q96SW2 3/20 0.34
SYK P43405 3/20 0.33
MAPK8 P45983 2/20 0.33
SIK1 P57059 2/20 0.33
SIK2 Q9H0K1 2/20 0.33
SIK3 Q9Y2K2 2/20 0.33
CDK4 P11802 3/20 0.32
CSF1R P07333 2/20 0.32
CDK6 Q00534 2/20 0.32
CCNT1 O60563 2/20 0.32
CDK9 P50750 2/20 0.32
CCNK O75909 1/20 0.32
CCNA2 P20248 1/20 0.32
CDK2 P24941 1/20 0.32
CDK7 P50613 1/20 0.32
CCNH P51946 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333963 1.00 MEN1 (0.35) MEN1MAPTKMT2ADDB1CRBN
SCHEMBL31333777 1.00 MEN1 (0.35) MEN1MAPTKMT2ADDB1CRBN
SCHEMBL31333382 1.00 MEN1 (0.35) MEN1MAPTKMT2ADDB1CRBN
SCHEMBL31335037 1.00 MEN1 (0.35) MEN1MAPTKMT2ADDB1CRBN
SCHEMBL31333887 1.00 MEN1 (0.35) MEN1MAPTKMT2ADDB1CRBN
SCHEMBL31333358 1.00 MEN1 (0.35) MEN1MAPTKMT2ADDB1CRBN
SCHEMBL31333350 0.96 CDK4 (0.34) MEN1MAPTKMT2ADDB1CRBN
SCHEMBL31333329 0.95 CDK4 (0.34) MEN1MAPTKMT2ADDB1CRBN
SCHEMBL31334396 0.95 BTK (0.37) MEN1MAPTKMT2ADDB1CRBN
SCHEMBL31334478 0.92 MEN1 (0.39) MEN1MAPTKMT2ADDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed