SCHEMBL31334263

SCHEMBL31334263

COC(=O)[C@H]1CC[C@H](Nc2ncc(F)c(-c3cccc(-n4ccccc4=O)c3)n2)CC1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SYK P43405 3/20 0.43
MAPK1 P28482 6/20 0.42
PCSK9 Q8NBP7 2/20 0.41
ADORA2A P29274 6/20 0.40
CDK2 P24941 2/20 0.40
CCNA2 P20248 1/20 0.40
MAPK3 P27361 1/20 0.40
ADORA1 P30542 5/20 0.40
F10 P00742 1/20 0.38
CCNB2 O95067 1/20 0.38
CCNE2 O96020 1/20 0.38
CDK1 P06493 1/20 0.38
CCNB1 P14635 1/20 0.38
CCNE1 P24864 1/20 0.38
CDK5 Q00535 1/20 0.38
CDK5R1 Q15078 1/20 0.38
CCNB3 Q8WWL7 1/20 0.38
PDGFRB P09619 1/20 0.37
PDGFRA P16234 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334507 1.00 SYK (0.43) SYKMAPK1PCSK9ADORA2ACDK2
SCHEMBL31334829 0.93 SYK (0.42) SYKMAPK1PCSK9ADORA2ACDK2
SCHEMBL31333260 0.91 SYK (0.43) SYKMAPK1PCSK9ADORA2ACDK2
SCHEMBL31333268 0.91 SYK (0.46) SYKMAPK1PCSK9ADORA2ACDK2
SCHEMBL31333776 0.91 SYK (0.46) SYKMAPK1PCSK9ADORA2ACDK2
SCHEMBL31334709 0.90 SYK (0.48) SYKMAPK1PCSK9ADORA2ACDK2
SCHEMBL31334896 0.90 SYK (0.48) SYKMAPK1PCSK9ADORA2ACDK2
SCHEMBL31334356 0.89 MAPK1 (0.39) MAPK1ADORA2ACDK2CCNA2MAPK3
SCHEMBL31334136 0.89 MAPK1 (0.39) MAPK1ADORA2ACDK2CCNA2MAPK3
SCHEMBL31334380 0.88 MAPK1 (0.41) SYKMAPK1PCSK9ADORA2ACDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed