SCHEMBL31334342

SCHEMBL31334342

CC(C)(C)OC(=O)N[C@H]1CC[C@H](Nc2ncc(F)c(-c3ccnc(N4CCCOC4=O)c3)n2)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 7/20 0.47
CKS1B P61024 1/20 0.40
SKP1 P63208 1/20 0.40
SKP2 Q13309 1/20 0.40
DYRK2 Q92630 2/20 0.39
MERTK Q12866 1/20 0.37
CDK2 P24941 3/20 0.36
CCNA2 P20248 2/20 0.36
MAPK3 P27361 1/20 0.36
CDK4 P11802 2/20 0.36
CCND1 P24385 2/20 0.36
CCND3 P30281 2/20 0.36
CDK6 Q00534 2/20 0.36
SYK P43405 2/20 0.36
ALOX5AP P20292 1/20 0.36
FEN1 P39748 1/20 0.36
NTRK1 P04629 1/20 0.36
KDM4D Q6B0I6 1/20 0.35
CCNT1 O60563 1/20 0.35
CDK9 P50750 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334131 0.95 MAPK1 (0.48) MAPK1CKS1BSKP1SKP2DYRK2
SCHEMBL31334974 0.89 MAPK1 (0.41) MAPK1DYRK2CDK2CCNA2MAPK3
SCHEMBL31333344 0.89 MAPK1 (0.46) MAPK1CKS1BSKP1SKP2DYRK2
SCHEMBL31333298 0.88 MAPK1 (0.47) MAPK1CKS1BSKP1SKP2DYRK2
SCHEMBL31333733 0.88 MAPK1 (0.45) MAPK1CKS1BSKP1SKP2DYRK2
SCHEMBL31334133 0.87 MAPK1 (0.49) MAPK1CKS1BSKP1SKP2DYRK2
SCHEMBL31333533 0.87 MAPK1 (0.43) MAPK1CKS1BSKP1SKP2MERTK
SCHEMBL31333326 0.86 MAPK1 (0.41) MAPK1DYRK2CDK2CCNA2MAPK3
SCHEMBL31333500 0.85 MAPK1 (0.40) MAPK1DYRK2CDK2CCNA2MAPK3
SCHEMBL31334213 0.85 MAPK1 (0.40) MAPK1DYRK2CDK2CCNA2MAPK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed