SCHEMBL31334873

SCHEMBL31334873

COC(=O)c1cccc(-c2nc(NC3CCN(C(C)=O)CC3)ncc2F)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 6/20 0.47
CDK1 P06493 4/20 0.47
CDK4 P11802 3/20 0.47
CCND1 P24385 3/20 0.47
MAPK14 Q16539 1/20 0.47
DYRK2 Q92630 4/20 0.46
CCNB1 P14635 2/20 0.44
CCNE1 P24864 2/20 0.44
CDK5 Q00535 2/20 0.44
CDK5R1 Q15078 2/20 0.44
CCNB2 O95067 1/20 0.44
CCNE2 O96020 1/20 0.44
CCNB3 Q8WWL7 1/20 0.44
IRAK1 P51617 1/20 0.44
IRAK4 Q9NWZ3 1/20 0.44
MAPK1 P28482 6/20 0.43
CCNA2 P20248 3/20 0.43
CCNA1 P78396 3/20 0.43
GSK3B P49841 1/20 0.43
CCND3 P30281 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333408 0.91 DYRK2 (0.48) CDK2CDK1CDK4CCND1MAPK14
SCHEMBL31334440 0.88 IRAK1 (0.49) CDK2CDK1CDK4CCND1MAPK14
SCHEMBL31333835 0.87 MCHR1 (0.44) CDK2CDK1MAPK14CCNB1CCNE1
SCHEMBL31333202 0.86 DYRK2 (0.48) CDK2CDK1CDK4CCND1MAPK14
SCHEMBL31334503 0.86 DYRK2 (0.49) CDK2CDK4CCND1DYRK2CCNE1
SCHEMBL31334011 0.86 DYRK2 (0.49) CDK2CDK4CCND1DYRK2CCNE1
SCHEMBL31334738 0.85 DYRK2 (0.43) CDK2CDK1CDK4CCND1MAPK14
SCHEMBL31333629 0.84 CDK2 (0.47) CDK2CDK1CDK4CCND1MAPK14
SCHEMBL31334805 0.84 CDK2 (0.49) CDK2CDK1CDK4CCND1MAPK14
SCHEMBL31334225 0.83 MAPK14 (0.45) CDK2CDK1CDK4CCND1MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed