Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4204490 | 0.91 | ESR2 (0.49) | ESR2NR1H2MAPTGRAMD1ADDB1 | |
| SCHEMBL10313013 | 0.84 | ESR2 (0.57) | ESR2NR1H2MAPTPARP1TNKS2 | |
| SCHEMBL21041656 | 0.84 | ESR2 (0.61) | ESR2NR1H2MAPTPARP1TNKS2 | |
| SCHEMBL30013710 | 0.84 | ESR2 (0.61) | ESR2NR1H2MAPTPARP1TNKS2 | |
| SCHEMBL16691229 | 0.82 | NR1H2 (0.62) | ESR2NR1H2MAPTPARP1TNKS2 | |
| SCHEMBL29712352 | 0.82 | ESR2 (0.60) | ESR2NR1H2MAPTPARP1TNKS2 | |
| SCHEMBL12540273 | 0.82 | ESR2 (0.60) | ESR2NR1H2MAPTPARP1TNKS2 | |
| SCHEMBL22981578 | 0.82 | ESR2 (0.53) | ESR2NR1H2MAPTPARP1TNKS2 | |
| SCHEMBL21326148 | 0.81 | ESR2 (0.55) | ESR2NR1H2MAPTPARP1TNKS2 | |
| SCHEMBL31484029 | 0.81 | ESR2 (0.49) | ESR2NR1H2MAPTGRAMD1ADDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4720038-A1 | (HETERO)ARYL-CARBONYL-HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PMS2 FOR CANCER AND DEGENERATIVE ILLNESSES | Neophore Limited (GB) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024246496-A1 | (HETERO)ARYL-CARBONYL-HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PMS2 FOR CANCER AND DEGENERATIVE ILLNESSES | Neophore Limited (GB) | 2024-12-05 | — | — | WO | disclosed |