Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3122691 | 0.90 | IGF1R (0.41) | IGF1RMAPK8ABL1BCRINSR | |
| SCHEMBL2209019 | 0.86 | IGF1R (0.51) | IGF1RMAPK8ABL1BCRKMT2A | |
| SCHEMBL3133614 | 0.76 | IGF1R (0.58) | IGF1RMAPK8INSRALKGRK2 | |
| SCHEMBL3133066 | 0.76 | IGF1R (0.57) | IGF1RMAPK8INSRALKGRK2 | |
| SCHEMBL3265898 | 0.75 | IGF1R (0.44) | IGF1RMAPK8ABL1BCRKMT2A | |
| SCHEMBL3124996 | 0.75 | IGF1R (0.58) | IGF1RMAPK8INSRALKGRK2 | |
| SCHEMBL3122538 | 0.74 | IGF1R (0.59) | IGF1RMAPK8INSRALKGRK2 | |
| SCHEMBL3127904 | 0.73 | IGF1R (0.51) | IGF1RMAPK8INSRALKGRK2 | |
| SCHEMBL2206637 | 0.73 | CDK4 (0.40) | IGF1RMAPK8KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL3128720 | 0.73 | IGF1R (0.52) | IGF1RINSRALKGRK2GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045451-A1 | PYRROLOPYRIMIDINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-22 | — | — | WO | disclosed |