SCHEMBL31347007

SCHEMBL31347007

COC(=O)c1nc(Cl)cc(Br)c1C

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.44
KDM4E B2RXH2 8/20 0.41
SMN1; SMN2 Q16637 4/20 0.38
MAPT P10636 1/20 0.38
XDH P47989 1/20 0.38
ALDH1A1 P00352 8/20 0.38
S1PR4 O95977 1/20 0.37
GABRA2 P47869 1/20 0.36
GABRB2 P47870 1/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
HPGD P15428 2/20 0.36
PKM P14618 2/20 0.36
RCE1 Q9Y256 1/20 0.36
ATM Q13315 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
HSD17B10 Q99714 1/20 0.35
POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26109972 1.00 NPSR1 (0.44) NPSR1KDM4ESMN1; SMN2MAPTXDH
SCHEMBL26289357 0.83 NPSR1 (0.47) NPSR1KDM4ESMN1; SMN2ALDH1A1S1PR4
SCHEMBL31330704 0.82 NPSR1 (0.42) NPSR1KDM4ESMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL535659 0.82 NPSR1 (0.42) NPSR1KDM4ESMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL2599584 0.80 KDM4E (0.45) NPSR1KDM4ESMN1; SMN2MAPTALDH1A1
SCHEMBL31347168 0.80 NPSR1 (0.40) NPSR1KDM4ESMN1; SMN2MAPTXDH
SCHEMBL26102704 0.80 NPSR1 (0.40) NPSR1KDM4ESMN1; SMN2MAPTXDH
SCHEMBL30722739 0.78 KDM4E (0.39) NPSR1KDM4ESMN1; SMN2MAPTALDH1A1
SCHEMBL26988946 0.78 KDM4E (0.39) NPSR1KDM4ESMN1; SMN2MAPTALDH1A1
SCHEMBL1654747 0.78 NPSR1 (0.45) NPSR1KDM4ESMN1; SMN2MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119585252-A Bicyclic heteroaryl containing compounds as IKZF2 degrading agents 翁科皮亚治疗公司和SK生命科学实验室 2025-03-07 CN disclosed