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Sugi Predict / Compounds / SCHEMBL31348463

SCHEMBL31348463

SCHEMBL31348463

COCOc1cc(-c2nc(OC)c3c(N(C)C)nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)c2c(C#C[Si](C(C)C)(C(C)C)C(C)C)c(F)ccc2c1

nearest known ligand 0.50

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ KRAS P01116 17/20 0.50
▸ MAPK3 P27361 4/20 0.44
▸ MAPK1 P28482 4/20 0.44
▸ RAF1 P04049 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31662384 0.92 KRAS (0.48) KRASMAPK3MAPK1RAF1
SCHEMBL25402982 0.91 KRAS (0.48) KRASMAPK3MAPK1RAF1
SCHEMBL31348400 0.91 KRAS (0.60) KRASMAPK3MAPK1RAF1
SCHEMBL31662374 0.90 KRAS (0.46) KRASMAPK3MAPK1RAF1
SCHEMBL30702837 0.89 KRAS (0.50) KRASMAPK3MAPK1RAF1
SCHEMBL27243214 0.88 KRAS (0.48) KRASMAPK3MAPK1RAF1
SCHEMBL31661997 0.88 KRAS (0.47) KRASMAPK3MAPK1RAF1
SCHEMBL30702822 0.88 KRAS (0.48) KRASMAPK3MAPK1RAF1
SCHEMBL30702830 0.88 KRAS (0.49) KRASMAPK3MAPK1RAF1
SCHEMBL31662317 0.87 KRAS (0.43) KRASMAPK3MAPK1RAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735439-A1 KRAS INHIBITORS Bristol-Myers Squibb Company (US) 2026-05-06 — — EP disclosed
WO-2025006967-A1 KRAS INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-01-02 — — WO disclosed