SCHEMBL31348958

SCHEMBL31348958

N#Cc1ccc(C(=O)N(O)c2cccc(C(=O)Nc3c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc3C(F)(F)F)c2F)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 2/20 0.39
SMO Q99835 1/20 0.33
TRPV1 Q8NER1 1/20 0.33
ABCC9 O60706 1/20 0.32
ABCC8 Q09428 1/20 0.32
KCNJ11 Q14654 1/20 0.32
KCNJ8 Q15842 1/20 0.32
TMPRSS4 Q9NRS4 1/20 0.32
HSD11B1 P28845 1/20 0.32
TRPM8 Q7Z2W7 1/20 0.31
VNN1 O95497 1/20 0.31
TRPA1 O75762 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
LRRK2 Q5S007 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
NR1H4 Q96RI1 1/20 0.31
MLYCD O95822 2/20 0.31
KAT6A Q92794 1/20 0.30
MAPT P10636 1/20 0.30
XBP1 P17861 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1766929 0.91 RXFP1 (0.39) RXFP1SMOTRPV1ABCC9ABCC8
SCHEMBL31348975 0.91 SMN1; SMN2 (0.33) RXFP1KCNJ11HDAC8LRRK2SMN1; SMN2
SCHEMBL31348985 0.90 RXFP1 (0.41) RXFP1SMOTRPV1ABCC9ABCC8
SCHEMBL31348873 0.90 KCNK3 (0.39) RXFP1KCNJ11HDAC8SMN1; SMN2KAT6A
SCHEMBL29161180 0.88 SCN10A (0.35) RXFP1HDAC8
SCHEMBL1766397 0.87 RXFP1 (0.37) RXFP1SMOTRPV1HSD11B1VNN1
SCHEMBL31348965 0.87 HDAC8 (0.32) RXFP1KCNJ11HDAC8SMN1; SMN2MAPT
SCHEMBL12569845 0.86 RXFP1 (0.35) RXFP1VNN1MLYCD
SCHEMBL21693605 0.86 RXFP1 (0.35) RXFP1SMOHSD11B1HDAC8MLYCD
SCHEMBL22029470 0.86 RXFP1 (0.37) RXFP1SMOTRPV1ABCC9ABCC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119059936-A Meta-aminobenzoic acid bisamide compound 湖南化工研究院有限公司 2024-12-03 CN claimed