Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Valganciclovir. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HBB | P68871 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | VCP | P55072 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | HPRT1 | P00492 | 9/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | PNP | P00491 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (S)-Valganciclovir SCHEMBL28997 | 0.91 | PDE3A (0.74) | PDE3AMEN1KMT2AHBBBLM | |
| Valganciclovir SCHEMBL28996 | 0.91 | PDE3A (0.74) | PDE3AMEN1KMT2AHBBBLM | |
| Valganciclovir SCHEMBL23225 | 0.90 | PDE3A (0.73) | PDE3AMEN1KMT2AHBBBLM | |
| Valganciclovir SCHEMBL1652839 | 0.89 | PDE3A (0.71) | PDE3AMEN1KMT2AHBBBLM | |
| Valganciclovir SCHEMBL3237941 | 0.89 | PDE3A (0.70) | PDE3AMEN1KMT2AHBBBLM | |
| Valganciclovir SCHEMBL6479139 | 0.85 | PDE3A (0.68) | PDE3AMEN1KMT2AHBBBLM | |
| Valganciclovir SCHEMBL1120942 | 0.84 | PDE3A (0.85) | PDE3AMEN1KMT2AHBBBLM | |
| Valganciclovir SCHEMBL15251689 | 0.83 | PDE3A (0.83) | PDE3AMEN1KMT2AHBBBLM | |
| Valganciclovir SCHEMBL336814 | 0.80 | PDE3A (0.78) | PDE3AMEN1KMT2AHBBBLM | |
| Valganciclovir SCHEMBL18837501 | 0.80 | PDE3A (0.77) | PDE3AMEN1KMT2AHBBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203192-A1 | WOUND CARE FORMULATION | Northern Health And Social Care Trust (GB) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009037500-A1 | WOUND CARE FORMULATION | NORTHERN HEALTH AND SOCIAL CARE TRUST (GB) | 2009-03-26 | — | — | WO | disclosed |