Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3135738 | 1.00 | CA12 (0.43) | CA12CA9KMT2AMEN1GAA | |
| SCHEMBL3135749 | 1.00 | CA12 (0.43) | CA12CA9KMT2AMEN1GAA | |
| SCHEMBL3806083 | 0.84 | HSD17B10 (0.40) | KMT2AMEN1GAAHSD17B10ALDH1A1 | |
| SCHEMBL3806090 | 0.84 | HSD17B10 (0.40) | KMT2AMEN1GAAHSD17B10ALDH1A1 | |
| SCHEMBL3806087 | 0.84 | HSD17B10 (0.40) | KMT2AMEN1GAAHSD17B10ALDH1A1 | |
| SCHEMBL3133513 | 0.83 | CA12 (0.48) | CA12CA9KMT2AMEN1GAA | |
| SCHEMBL3132153 | 0.82 | HSD17B10 (0.47) | CA12CA9KMT2AMEN1GAA | |
| SCHEMBL3560372 | 0.82 | HSD17B10 (0.47) | CA12CA9KMT2AMEN1GAA | |
| SCHEMBL3139368 | 0.82 | CA12 (0.47) | CA12CA9KMT2AMEN1GAA | |
| SCHEMBL3564500 | 0.82 | HSD17B10 (0.47) | CA12CA9KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056633-A2 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2010-05-20 | — | — | WO | disclosed |