Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 9/20 | 0.67 |
| ▸ | MEN1 | O00255 | 8/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.67 |
| ▸ | AKT1 | P31749 | 1/20 | 0.67 |
| ▸ | PPM1G | O15355 | 1/20 | 0.67 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.67 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.67 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.67 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.67 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.58 |
| ▸ | GSK3A | P49840 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13072371 | 0.89 | AKT1 (0.60) | PIM1POLBMEN1KMT2AMAPT | |
| SCHEMBL31358833 | 0.86 | PIK3CG (0.61) | PIM1POLBMEN1KMT2AMAPT | |
| SCHEMBL31358710 | 0.86 | MEN1 (0.68) | PIM1POLBMEN1KMT2AMAPT | |
| SCHEMBL700410 | 0.84 | PIM1 (1.00) | PIM1POLBMEN1KMT2AMAPT | |
| SCHEMBL700411 | 0.84 | PIM1 (1.00) | PIM1POLBMEN1KMT2AMAPT | |
| SCHEMBL31434334 | 0.84 | PIM1 (1.00) | PIM1POLBMEN1KMT2AMAPT | |
| SCHEMBL31358723 | 0.84 | MEN1 (0.72) | PIM1POLBMEN1KMT2AMAPT | |
| SCHEMBL31358750 | 0.83 | POLB (0.69) | PIM1POLBMEN1KMT2AMAPT | |
| SCHEMBL10091431 | 0.82 | PIM1 (0.62) | PIM1POLBMEN1KMT2AMAPT | |
| SCHEMBL6721181 | 0.82 | PTPN5 (0.71) | PIM1POLBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2025-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | PTPN18, PTPN7, PTPN1 | PIM1 695/4885POLB 3743/4885MEN1 2467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.