Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.57 |
| ▸ | PKM | P14618 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 11/20 | 0.52 |
| ▸ | MEN1 | O00255 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | HTRA2 | O43464 | 1/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.52 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31358665 | 0.86 | KMT2A (0.73) | KMT2ANPSR1PKMKDM4EBRAF | |
| SCHEMBL31358680 | 0.86 | KMT2A (0.58) | KMT2ANPSR1PKMKDM4EBRAF | |
| SCHEMBL31358780 | 0.86 | KMT2A (0.57) | KMT2ANPSR1PKMKDM4EBRAF | |
| SCHEMBL31358739 | 0.83 | MAPT (0.64) | KMT2ANPSR1PKMKDM4EBRAF | |
| SCHEMBL31358668 | 0.83 | MAPT (0.51) | KMT2ANPSR1PKMKDM4EBRAF | |
| SCHEMBL31358724 | 0.83 | PIK3CG (0.56) | KMT2ANPSR1PKMKDM4EMAPT | |
| SCHEMBL31358800 | 0.82 | KMT2A (0.60) | KMT2ANPSR1PKMKDM4EBRAF | |
| SCHEMBL31358847 | 0.80 | GSK3A (0.58) | KMT2ANPSR1PKMKDM4EBRAF | |
| SCHEMBL31358735 | 0.79 | KMT2A (0.57) | KMT2ANPSR1PKMKDM4EBRAF | |
| SCHEMBL31358808 | 0.79 | KMT2A (0.57) | KMT2ANPSR1PKMKDM4EBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2025-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | PTPN18, PTPN7, PTPN1 | KMT2A 1043/4885NPSR1 4230/4885PKM 4300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.