Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | POLB | P06746 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.57 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | PPM1G | O15355 | 1/20 | 0.57 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.57 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.57 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.57 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.57 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.56 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.56 |
| ▸ | PTPRC | P08575 | 1/20 | 0.53 |
| ▸ | PTPRF | P10586 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31358657 | 0.87 | MAPT (0.65) | SIRT2MEN1KMT2AMAPTPOLB | |
| SCHEMBL31358833 | 0.87 | PIK3CG (0.61) | SIRT2MEN1KMT2AMAPTPOLB | |
| SCHEMBL31358710 | 0.85 | MEN1 (0.68) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL31358678 | 0.82 | KDM4E (0.70) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL31358826 | 0.82 | KMT2A (0.64) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL31358740 | 0.82 | SIRT2 (0.53) | SIRT2MEN1KMT2AMAPTPOLB | |
| SCHEMBL31358764 | 0.82 | AKT1 (0.62) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL31358773 | 0.80 | MEN1 (0.69) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL31358723 | 0.80 | MEN1 (0.72) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL5163809 | 0.80 | SIRT2 (1.00) | SIRT2MEN1KMT2AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2025-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | PTPN18, PTPN7, PTPN1 | SIRT2 4314/4885MEN1 2467/4885KMT2A 1043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.