Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 11/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.36 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.35 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30900255 | 1.00 | PRMT5 (0.38) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL21683329 | 1.00 | PRMT5 (0.38) | PRMT5WDR77PI4KAPI4K2BPI4K2A | |
| SCHEMBL22577644 | 0.83 | PI4KA (0.47) | PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL21683402 | 0.80 | PRMT5 (0.34) | PRMT5WDR77 | |
| SCHEMBL21683404 | 0.80 | PRMT5 (0.34) | PRMT5WDR77 | |
| SCHEMBL23780924 | 0.80 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL21683321 | 0.80 | PRMT5 (0.34) | PRMT5WDR77 | |
| SCHEMBL21683319 | 0.80 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL21683325 | 0.80 | PRMT5 (0.42) | PRMT5WDR77METTL3METTL14 | |
| SCHEMBL4830277 | 0.80 | PRMT5 (0.42) | PRMT5WDR77METTL3METTL14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3833668-B1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-03-19 | — | — | EP | disclosed |