Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 17/20 | 0.58 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.58 |
| ▸ | METTL3 | Q86U44 | 7/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21684273 | 1.00 | PRMT5 (0.58) | PRMT5WDR77METTL3 | |
| SCHEMBL21683375 | 0.91 | PRMT5 (0.69) | PRMT5WDR77METTL3 | |
| SCHEMBL31361574 | 0.91 | PRMT5 (0.69) | PRMT5WDR77METTL3 | |
| SCHEMBL21683378 | 0.89 | PRMT5 (0.59) | PRMT5WDR77METTL3 | |
| SCHEMBL21683411 | 0.88 | PRMT5 (0.55) | PRMT5WDR77METTL3 | |
| SCHEMBL31361600 | 0.88 | PRMT5 (0.55) | PRMT5WDR77METTL3 | |
| SCHEMBL21683416 | 0.87 | PRMT5 (0.55) | PRMT5WDR77METTL3 | |
| SCHEMBL30900262 | 0.82 | PRMT5 (0.54) | PRMT5WDR77METTL3 | |
| SCHEMBL21683384 | 0.81 | PRMT5 (0.55) | PRMT5WDR77METTL3 | |
| SCHEMBL21683385 | 0.81 | PRMT5 (0.55) | PRMT5WDR77METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3833668-B1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-03-19 | — | — | EP | disclosed |