Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.83 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.83 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.83 |
| ▸ | KDR | P35968 | 14/20 | 0.77 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | STK10 | O94804 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31362718 | 0.92 | RET (0.88) | RETMAP3K20RIPK3KDRNPC1 | |
| Rivoceranib SCHEMBL29360856 | 0.91 | RET (1.00) | RETMAP3K20RIPK3KDRNPC1 | |
| Rivoceranib SCHEMBL1814966 | 0.91 | RET (1.00) | RETMAP3K20RIPK3KDRNPC1 | |
| SCHEMBL6014666 | 0.90 | RET (0.98) | RETMAP3K20RIPK3KDRNPC1 | |
| SCHEMBL6014575 | 0.89 | RET (0.96) | RETMAP3K20RIPK3KDRNPC1 | |
| SCHEMBL31362698 | 0.87 | RET (0.83) | RETMAP3K20RIPK3KDRNPC1 | |
| SCHEMBL6014552 | 0.87 | RET (0.93) | RETMAP3K20RIPK3KDRABCB1 | |
| Rivoceranib SCHEMBL21847695 | 0.87 | KDR (1.00) | RETMAP3K20RIPK3KDRNPC1 | |
| SCHEMBL31362723 | 0.83 | RET (0.73) | RETMAP3K20RIPK3KDRNPC1 | |
| SCHEMBL31362711 | 0.81 | RET (0.70) | RETMAP3K20RIPK3KDRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025024564-A1 | SMALL MOLECULES THAT PREVENT STATIN-INDUCED ACCUMULATION OF HMG COA REDUCTASE | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2025-01-30 | — | — | WO | disclosed |