SCHEMBL31367074

SCHEMBL31367074

CCOc1c(C(C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C)c1C1CNC1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 20/20 0.79
KCNH2 Q12809 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14736232 1.00 PIK3CD (0.79) PIK3CDKCNH2
SCHEMBL14753932 0.92 PIK3CD (0.84) PIK3CD
SCHEMBL18258773 0.91 PIK3CD (0.79) PIK3CDKCNH2
Hydrochloric Acid SCHEMBL14736258 0.91 PIK3CD (0.83) PIK3CD
Hydrochloric Acid SCHEMBL14736155 0.91 PIK3CD (0.83) PIK3CD
Hydrochloric Acid SCHEMBL29510765 0.91 PIK3CD (0.83) PIK3CD
Hydrochloric Acid SCHEMBL29510916 0.91 PIK3CD (0.83) PIK3CD
Hydrochloric Acid SCHEMBL29715608 0.91 PIK3CD (0.83) PIK3CD
Hydrochloric Acid SCHEMBL14736513 0.91 PIK3CD (0.78) PIK3CDKCNH2
Hydrochloric Acid SCHEMBL29836122 0.91 PIK3CD (0.78) PIK3CDKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3888657-B1 HETEROCYCLYLAMINES AS PI3K INHIBITORS INCYTE HOLDINGS CORP (US) 2025-03-19 EP disclosed