SCHEMBL31367086

SCHEMBL31367086

CCCN1CC(c2c(C)c(Cl)cc(C(C)n3nc(C)c4c(N)ncnc43)c2OCC)C1

nearest known ligand 0.72

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 18/20 0.72
AXL P30530 2/20 0.61
MERTK Q12866 2/20 0.61
KCNH2 Q12809 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31367085 0.94 PIK3CD (0.80) PIK3CDAXLMERTK
SCHEMBL16005855 0.94 PIK3CD (0.80) PIK3CDAXLMERTK
SCHEMBL30590258 0.93 AXL (0.71) PIK3CDAXLMERTKKCNH2
SCHEMBL14752198 0.93 AXL (0.71) PIK3CDAXLMERTKKCNH2
SCHEMBL31367065 0.91 PIK3CD (0.73) PIK3CDAXLMERTKKCNH2
SCHEMBL31367092 0.91 PIK3CD (0.72) PIK3CDAXLMERTKKCNH2
SCHEMBL14752105 0.90 PIK3CD (0.73) PIK3CDKCNH2
SCHEMBL14752106 0.90 PIK3CD (0.71) PIK3CDAXLMERTKKCNH2
SCHEMBL31441214 0.90 PIK3CD (0.71) PIK3CDAXLMERTKKCNH2
SCHEMBL19639739 0.90 PIK3CD (0.71) PIK3CDAXLMERTKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3888657-B1 HETEROCYCLYLAMINES AS PI3K INHIBITORS INCYTE HOLDINGS CORP (US) 2025-03-19 EP disclosed