SCHEMBL3136947

SCHEMBL3136947

CCN(CC)CCc1c(C(F)(F)F)c2ccc(O)cc2oc1=O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B3 P37058 8/20 0.60
ESR1 P03372 6/20 0.60
AR P10275 1/20 0.60
NQO1 P15559 1/20 0.47
CYP2C9 P11712 1/20 0.47
XDH P47989 1/20 0.47
KDM4E B2RXH2 4/20 0.46
GLA P06280 4/20 0.46
GAA P10253 4/20 0.46
ALDH1A1 P00352 3/20 0.46
HPGD P15428 3/20 0.46
CASP1 P29466 2/20 0.46
CASP7 P55210 2/20 0.46
HSD17B10 Q99714 2/20 0.46
TSHR P16473 1/20 0.46
MAOA P21397 2/20 0.45
MAOB P27338 1/20 0.45
NPSR1 Q6W5P4 1/20 0.43
ERAP1 Q9NZ08 1/20 0.43
MEN1 O00255 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7141330 0.84 CYP2C9 (0.64) HSD17B3ESR1ARNQO1CYP2C9
SCHEMBL1476174 0.83 HSD17B3 (0.74) HSD17B3ESR1NQO1XDHKDM4E
Hydrochloric Acid SCHEMBL334089 0.82 HSD17B3 (0.72) HSD17B3NQO1XDHKDM4EGLA
Hydrochloric Acid SCHEMBL7145361 0.81 HSD17B3 (0.70) HSD17B3ESR1NQO1XDHKDM4E
SCHEMBL6200660 0.78 ERAP1 (0.56) HSD17B3ESR1ARNQO1CYP2C9
SCHEMBL14384569 0.77 CYP2C9 (0.70) HSD17B3ESR1ARNQO1CYP2C9
SCHEMBL5284518 0.76 KDM4E (0.60) HSD17B3ESR1ARNQO1CYP2C9
SCHEMBL10637081 0.74 HSD17B3 (0.69) HSD17B3ESR1ARCYP2C9KDM4E
SCHEMBL14111526 0.71 AKR1B1 (0.56) HSD17B3ESR1ARCYP2C9KDM4E
SCHEMBL10794465 0.70 HSD17B3 (0.73) HSD17B3ESR1NQO1KDM4EGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010010343-A1 STABILISATION DE MONTFORT UNIVERSITY (GB) 2010-01-28 WO disclosed
EP-1095032-B1 REAGENTS FOR CYP2D FLUORESCENT ASSAY GENTEST CORP (US) 2003-12-10 EP disclosed
EP-1095032-A1 NOVEL CYP2D FLUORESCENT ASSAY REAGENTS GENTEST CORPORATION (US) 2001-05-02 EP disclosed
US-6130342-A A 2-OXOCHROMAN COMPOUND CONTAINING A QUATERNARY AMINE GROUP GENTEST CORPORATION (US) 2000-10-10 US disclosed
WO-2000004008-A1 NOVEL CYP2D FLUORESCENT ASSAY REAGENTS GENTEST CORPORATION (US) 2000-01-27 WO disclosed