Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 9/20 | 0.62 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30808784 | 0.81 | JAK1 (0.54) | JAK1JAK2KMT2AL3MBTL1JAK3 | |
| SCHEMBL30808804 | 0.80 | JAK1 (0.58) | JAK1JAK2KMT2AL3MBTL1TYK2 | |
| SCHEMBL25597839 | 0.80 | JAK1 (0.49) | JAK1JAK2KMT2AL3MBTL1KDM1A | |
| SCHEMBL31376669 | 0.80 | JAK1 (0.42) | JAK1JAK2KMT2AJAK3DRD2 | |
| SCHEMBL30808803 | 0.77 | JAK1 (0.54) | JAK1JAK2KMT2AL3MBTL1KDM1A | |
| SCHEMBL30808806 | 0.77 | JAK1 (0.54) | JAK1JAK2KMT2AL3MBTL1KDM1A | |
| SCHEMBL2277170 | 0.77 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL12385110 | 0.77 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL22511963 | 0.77 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL12385125 | 0.77 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739670-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025012057-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-16 | — | — | WO | disclosed |