Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | JAK3 | P52333 | 3/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.43 |
| ▸ | GRM5 | P41594 | 4/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31379867 | 0.87 | JAK2 (0.41) | JAK2JAK3PTK2GRM5GRM1 | |
| SCHEMBL31379900 | 0.86 | APP (0.48) | JAK2JAK3PTK2GRM5GRM1 | |
| SCHEMBL31379912 | 0.85 | SCN9A (0.45) | JAK2JAK3PTK2GRM5GRM1 | |
| SCHEMBL31379870 | 0.84 | GRM5 (0.42) | JAK2JAK3PTK2GRM5GRM1 | |
| SCHEMBL31379922 | 0.84 | NAMPT (0.41) | JAK2JAK3PTK2GRM5GRM1 | |
| SCHEMBL31379894 | 0.83 | NAMPT (0.41) | JAK2JAK3PTK2GRM5GRM1 | |
| SCHEMBL31379891 | 0.82 | SCN9A (0.46) | JAK2JAK3PTK2GRM5GRM1 | |
| SCHEMBL31379887 | 0.81 | SCN9A (0.42) | JAK2JAK3PTK2GRM5GRM1 | |
| SCHEMBL31379932 | 0.81 | PIK3CA (0.45) | JAK2JAK3PTK2GRM5GRM1 | |
| SCHEMBL31379895 | 0.79 | GRM1 (0.48) | JAK2JAK3PTK2GRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025027560-A1 | NEW RHOJ/CDC42 INHIBITORS DEVELOPED FOR THE TREATMENT OF CANCER, BENIGN TUMORS, RETINAL DISORDERS, VASCULAR DISORDERS, AND CARDIOMYOPATHIES | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2025-02-06 | — | — | WO | disclosed |