Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.71 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31064271 | 0.84 | HDAC1 (0.65) | HDAC1HDAC6P2RX7CXCR4HDAC3 | |
| SCHEMBL31064357 | 0.79 | HDAC1 (0.58) | HDAC1HDAC6P2RX7CXCR4 | |
| SCHEMBL31380390 | 0.78 | HDAC1 (0.55) | HDAC1HDAC6CXCR4HDAC8KMT2A | |
| SCHEMBL31324080 | 0.78 | HDAC1 (0.55) | HDAC1HDAC6CXCR4HDAC8KMT2A | |
| SCHEMBL30983271 | 0.77 | HDAC1 (0.56) | HDAC1HDAC6CXCR4HDAC3HDAC4 | |
| SCHEMBL30379489 | 0.77 | HDAC1 (0.61) | HDAC1HDAC6P2RX7CXCR4 | |
| SCHEMBL13909820 | 0.77 | HDAC1 (0.76) | HDAC1HDAC6P2RX7CXCR4KDM4E | |
| SCHEMBL3804425 | 0.75 | HDAC1 (0.57) | HDAC1HDAC6KDM1ACXCR4KMT2A | |
| SCHEMBL31064876 | 0.75 | HDAC1 (0.54) | HDAC1HDAC6P2RX7CXCR4ALDH1A1 | |
| SCHEMBL4562865 | 0.74 | HDAC1 (0.69) | HDAC1HDAC6CXCR4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025068985-A1 | 1-(1-OXO-1,2-DIHYDROPHTHALAZIN-6-YL)CYCLOALKYL-1-CARBOXAMIDE DERIVATIVES AS MTA-COOPERATIVE INHIBITORS OF PRMT5 | BEIGENE SWITZERLAND GMBH (CH) | 2025-04-03 | — | — | WO | disclosed |
| CN-119707931-A | Intermediate and synthesis method of 1- (1-oxo-1, 2-dihydro-phthalazin-6-yl) cycloalkyl-1-carboxamide derivatives as MTA synergistic inhibitors of PRMT5 | 百济神州(北京)生物科技有限公司 | 2025-03-28 | — | — | CN | disclosed |