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Sugi Predict / Compounds / SCHEMBL31382491

SCHEMBL31382491

SCHEMBL31382491

CC(C)(C)OC(=O)C1CCN(c2ccc([C@H]3CCC(=O)NC3=O)cc2)CC1.CC(C)(C)OC(=O)C1CCN(c2ccc([C@H]3CCC(=O)NC3=O)cc2)CC1

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 15/20 0.53
▸ DDB1 Q16531 14/20 0.53
▸ POLB P06746 1/20 0.46
▸ GPR119 Q8TDV5 4/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25198443 1.00 CRBN (0.53) CRBNDDB1POLBGPR119
SCHEMBL31382214 1.00 CRBN (0.53) CRBNDDB1POLBGPR119
SCHEMBL31382681 1.00 CRBN (0.53) CRBNDDB1POLBGPR119
SCHEMBL25205685 0.94 CRBN (0.51) CRBNDDB1POLBGPR119
SCHEMBL30981254 0.91 CRBN (0.49) CRBNDDB1POLB
SCHEMBL27023030 0.90 CRBN (0.49) CRBNDDB1POLBGPR119
SCHEMBL23301226 0.85 DDB1 (0.67) CRBNDDB1GPR119
SCHEMBL21876964 0.85 DDB1 (0.67) CRBNDDB1GPR119
SCHEMBL25143422 0.85 CRBN (0.53) CRBNDDB1POLBGPR119
SCHEMBL25184923 0.85 CRBN (0.54) CRBNDDB1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724435-A1 BIFUNCTIONAL AZINES CONJOGATES AS SELECTIVE DEGRADERS OF SMARCA2 AND THERAPEUTIC USES THEREOF Nurix Therapeutics, Inc. (US) 2026-04-15 — — EP disclosed
WO-2024254532-A1 BIFUNCTIONAL AZINES CONJOGATES AS SELECTIVE DEGRADERS OF SMARCA2 AND THERAPEUTIC USES THEREOF NURIX THERAPEUTICS, INC. (US) 2024-12-12 — — WO disclosed
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