Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | FECH | P22830 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31397183 | 1.00 | KHK (0.43) | KHKHTR1AHTR1DHTR1BBRPF1 | |
| SCHEMBL31397381 | 0.89 | MCHR1 (0.41) | KHKHTR1AMCHR1HRH4GRM5 | |
| SCHEMBL30273724 | 0.86 | MCHR1 (0.37) | MCHR1HRH4GRM5KCNH2PIK3CA | |
| SCHEMBL23541153 | 0.85 | LRRK2 (0.40) | BRPF1BRD4MCHR1HRH4GRM5 | |
| SCHEMBL31397170 | 0.84 | GRM5 (0.35) | ADORA3ADORA2AADORA1MCHR1HRH4 | |
| SCHEMBL24819652 | 0.84 | GRM5 (0.35) | ADORA3ADORA2AADORA1MCHR1HRH4 | |
| SCHEMBL24819651 | 0.84 | GRM5 (0.35) | ADORA3ADORA2AADORA1MCHR1HRH4 | |
| SCHEMBL31397420 | 0.84 | GRM5 (0.35) | ADORA3ADORA2AADORA1MCHR1HRH4 | |
| SCHEMBL31397259 | 0.84 | GRM5 (0.35) | ADORA3ADORA2AADORA1MCHR1HRH4 | |
| SCHEMBL31397188 | 0.84 | MCHR1 (0.36) | KHKMCHR1HRH4GRM5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240424111-A1 | Degrader Compounds and Uses Thereof | CALICO LIFE SCIENCES LLC (US) | 2024-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240424111-A1 | Degrader Compounds and Uses Thereof | PTPN1, PTPN2, PTPN5 | KHK 890/4885HTR1A 2408/4885HTR1D 2329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.