Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 15/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 15/20 | 0.37 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.33 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31397344 | 1.00 | DDB1 (0.37) | DDB1CRBNIKZF2IKZF1HDAC8 | |
| SCHEMBL31397445 | 0.92 | DDB1 (0.38) | DDB1CRBNIKZF2IKZF1HDAC8 | |
| SCHEMBL31397422 | 0.92 | DDB1 (0.38) | DDB1CRBNIKZF2IKZF1HDAC8 | |
| SCHEMBL23541155 | 0.91 | DDB1 (0.47) | DDB1CRBNIKZF2 | |
| SCHEMBL31397500 | 0.89 | DDB1 (0.40) | DDB1CRBNIKZF2IKZF1 | |
| SCHEMBL31397362 | 0.89 | DDB1 (0.40) | DDB1CRBNIKZF2IKZF1 | |
| SCHEMBL31397355 | 0.89 | DDB1 (0.43) | DDB1CRBN | |
| SCHEMBL31397603 | 0.89 | DDB1 (0.43) | DDB1CRBN | |
| SCHEMBL23540339 | 0.88 | DDB1 (0.41) | DDB1CRBNIKZF2IKZF1HDAC8 | |
| SCHEMBL31397401 | 0.85 | DDB1 (0.47) | DDB1CRBNIKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240424111-A1 | Degrader Compounds and Uses Thereof | CALICO LIFE SCIENCES LLC (US) | 2024-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240424111-A1 | Degrader Compounds and Uses Thereof | PTPN1, PTPN2, PTPN5 | DDB1 2296/4885CRBN 161/4885IKZF2 3265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.