Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cilnidipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 8/20 | 1.00 |
| ▸ | CACNA1F known ✓ | O60840 | 7/20 | 0.69 |
| ▸ | CACNA1D known ✓ | Q01668 | 7/20 | 0.69 |
| ▸ | CACNA1S known ✓ | Q13698 | 7/20 | 0.69 |
| ▸ | CACNA1B | Q00975 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | MLNR | O43193 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | CACNA1H | O95180 | 1/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cilnidipine SCHEMBL25550 | 1.00 | CACNA1C (1.00) | CACNA1CCACNA1BMEN1KMT2AADORA3 | |
| Cilnidipine SCHEMBL29367885 | 1.00 | CACNA1C (1.00) | CACNA1CCACNA1BMEN1KMT2AADORA3 | |
| Cilnidipine SCHEMBL25551 | 1.00 | CACNA1C (1.00) | CACNA1CCACNA1BMEN1KMT2AADORA3 | |
| Cilnidipine SCHEMBL30209784 | 1.00 | CACNA1C (1.00) | CACNA1CCACNA1BMEN1KMT2AADORA3 | |
| Cilnidipine SCHEMBL3334757 | 1.00 | CACNA1C (1.00) | CACNA1CCACNA1BMEN1KMT2AADORA3 | |
| Cilnidipine SCHEMBL28356318 | 0.99 | CACNA1C (0.98) | CACNA1CCACNA1BMEN1KMT2AADORA3 | |
| Cilnidipine SCHEMBL29248832 | 0.99 | CACNA1C (0.98) | CACNA1CCACNA1BMEN1KMT2AADORA3 | |
| Cilnidipine SCHEMBL27852253 | 0.97 | CACNA1C (0.95) | CACNA1CCACNA1BMEN1KMT2AADORA3 | |
| Cilnidipine SCHEMBL29141421 | 0.95 | CACNA1C (0.90) | CACNA1CCACNA1BMEN1KMT2AADORA3 | |
| SCHEMBL10739961 | 0.94 | CACNA1B (0.94) | CACNA1CCACNA1BMEN1KMT2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119438460-A | Method for detecting impurity content of cilnidipine optical isomer | 蚌埠丰原医药科技发展有限公司 | 2025-02-14 | — | — | CN | disclosed |