Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | ABL2 | P42684 | 2/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31398985 | 0.90 | SRC (0.43) | SRCEGFRABL1ABL2USP30 | |
| SCHEMBL31398872 | 0.86 | SRC (0.54) | SRCEGFRABL1ABL2TGFBR1 | |
| SCHEMBL31398881 | 0.86 | SRC (0.54) | SRCEGFRABL1ABL2TGFBR1 | |
| SCHEMBL31398996 | 0.81 | SRC (0.50) | SRCEGFRABL1ABL2USP30 | |
| SCHEMBL31398986 | 0.79 | MAP4K4 (0.44) | SRCEGFRABL1ABL2TGFBR1 | |
| SCHEMBL19731351 | 0.76 | SRC (0.61) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL18599165 | 0.76 | SRC (0.61) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL14706373 | 0.74 | EGFR (0.60) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL22658709 | 0.74 | SRC (0.52) | SRCEGFRABL1ABL2TGFBR1 | |
| SCHEMBL4824842 | 0.74 | EGFR (0.60) | SRCEGFRABL1ABL2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119176813-A | Tricyclic heterocyclic compound with FGFR inhibition effect, pharmaceutical composition containing tricyclic heterocyclic compound and application of pharmaceutical composition | 上海科恩泰生物医药科技有限公司 | 2024-12-24 | — | — | CN | disclosed |