Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | ABL2 | P42684 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452532 | 0.77 | SRC (0.44) | SRCEGFRMAP4K4PIK3CD | |
| SCHEMBL22676957 | 0.77 | SRC (0.44) | SRCEGFRMAP4K4PIK3CD | |
| SCHEMBL22658709 | 0.73 | SRC (0.52) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL29407628 | 0.73 | SRC (0.52) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL31398986 | 0.72 | MAP4K4 (0.44) | SRCEGFRMAP4K4ABL1ABL2 | |
| SCHEMBL31398896 | 0.70 | SRC (0.44) | SRCEGFRABL1ABL2 | |
| SCHEMBL15914116 | 0.69 | JAK2 (0.51) | SRCEGFRMAP4K4ABL1PIK3CD | |
| SCHEMBL31398885 | 0.69 | SRC (0.39) | SRCEGFRMAP4K4ABL1ABL2 | |
| SCHEMBL31398872 | 0.69 | SRC (0.54) | SRCEGFRABL1ABL2PIK3CD | |
| SCHEMBL31398881 | 0.69 | SRC (0.54) | SRCEGFRABL1ABL2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119176813-A | Tricyclic heterocyclic compound with FGFR inhibition effect, pharmaceutical composition containing tricyclic heterocyclic compound and application of pharmaceutical composition | 上海科恩泰生物医药科技有限公司 | 2024-12-24 | — | — | CN | disclosed |