Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ESPL1 | Q14674 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19461964 | 0.75 | CYP1A2 (0.40) | CYP1A2TDP1KDM4EMAPTNPC1 | |
| SCHEMBL31168662 | 0.75 | CYP1A2 (0.40) | CYP1A2TDP1KDM4EMAPTNPC1 | |
| SCHEMBL5201165 | 0.71 | CYP1A2 (0.61) | CYP1A2TDP1KDM4ECCR6CYP3A4 | |
| SCHEMBL21644467 | 0.70 | TDP1 (0.48) | CYP1A2TDP1KDM4EMAPTNPC1 | |
| SCHEMBL2596740 | 0.70 | CYP1A2 (0.46) | CYP1A2TDP1KDM4EMAPTNPC1 | |
| SCHEMBL21963269 | 0.70 | TDP1 (0.37) | CYP1A2TDP1KDM4EMAPTNPC1 | |
| SCHEMBL25786786 | 0.68 | CYP1A2 (0.56) | CYP1A2TDP1KDM4EMAPTHTT | |
| SCHEMBL942208 | 0.68 | TSHR (0.47) | CYP1A2TDP1KDM4EMAPTNPC1 | |
| SCHEMBL2100657 | 0.67 | TSHR (0.55) | CYP1A2TDP1KDM4EMAPTNPSR1 | |
| SCHEMBL10981846 | 0.67 | TSHR (0.55) | CYP1A2TDP1MAPTCCR6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |