Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187245 | 0.90 | KDR (0.63) | KDRABCB1ABL1CITMAP3K7 | |
| Hydrochloric Acid SCHEMBL445342 | 0.89 | KDR (0.62) | KDRABCB1ABL1CITMAP3K7 | |
| SCHEMBL444952 | 0.89 | KDR (0.62) | KDRRXFP1ABCB1ABL1CIT | |
| SCHEMBL6105803 | 0.86 | KDR (0.53) | KDRRXFP1ABCB1HTR2AHTR2C | |
| SCHEMBL3150882 | 0.84 | RXFP1 (0.46) | KDRRXFP1HTR2AHTR2CKIT | |
| SCHEMBL448213 | 0.83 | KDR (0.56) | KDRRXFP1ABCB1ABL1CIT | |
| SCHEMBL7017437 | 0.82 | KDR (0.53) | KDRRXFP1ABCB1HTR2AABL1 | |
| SCHEMBL7017655 | 0.81 | MAPT (0.53) | KDRRXFP1HTR2AHTR2C | |
| SCHEMBL447805 | 0.81 | MAPT (0.53) | KDRRXFP1HTR2AHTR2C | |
| SCHEMBL3892489 | 0.77 | KDR (0.55) | KDRRXFP1HTR2AHTR2CSLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261313-A1 | Substituted alkylamine derivatives and methods of use | AMGEN INC. | 2005-11-24 | — | — | US | claimed |
| EP-1537084-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | Amgen Inc. (US) | 2005-06-08 | — | — | EP | claimed |
| US-6878714-B2 | Substituted alkylamine derivatives and methods of use | AMGEN INC. (US) | 2005-04-12 | — | — | US | claimed |
| WO-2004007458-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | AMGEN INC. (US) | 2004-01-22 | — | — | WO | claimed |
| US-20030225106-A1 | Substituted alkylamine derivatives and methods of use | AMGEN INC. | 2003-12-04 | — | — | US | claimed |
| CN-104945382-A | Substituted piperidines that increase p53 activity and uses thereof | SCHERING CORP | 2015-09-30 | — | — | CN | disclosed |
| CN-102638981-B | Substituted piperidines that increase p53 activity and uses thereof | SCHERING CORP | 2015-07-22 | — | — | CN | disclosed |
| EP-1723156-B1 | PROCESS FOR THE PREPARATION OF PYRIDINE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2015-01-21 | — | — | EP | disclosed |
| US-7687643-B2 | Process for preparing 3,3-dimethylindolines | AMGEN INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687643-B2 | Process for preparing 3,3-dimethylindolines | AMGEN INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687643-B2 | Process for preparing 3,3-dimethylindolines | AMGEN INC. (US) | 2010-03-30 | — | — | US | disclosed |
| US-7687632-B2 | Process for the preparation of pyridine derivatives | DOW AGROSCIENCES LLC (US) | 2010-03-30 | — | — | US | disclosed |
| US-20070249837-A1 | Process for the Preparation of Pyridine Derivatives | CORTEVA AGRISCIENCE LLC | 2007-10-25 | — | — | US | disclosed |
| EP-1723156-A1 | PROCESS FOR THE PREPARATION OF PYRIDINE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2006-11-22 | — | — | EP | disclosed |
| US-20050261313-A1 | Substituted alkylamine derivatives and methods of use | AMGEN INC. | 2005-11-24 | — | — | US | disclosed |
| WO-2005063780-A1 | PROCESS FOR THE PREPARATION OF PYRIDINE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2005-07-14 | — | — | WO | disclosed |
| EP-1537084-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | Amgen Inc. (US) | 2005-06-08 | — | — | EP | disclosed |
| US-6878714-B2 | Substituted alkylamine derivatives and methods of use | AMGEN INC. (US) | 2005-04-12 | — | — | US | disclosed |
| WO-2004007458-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | AMGEN INC. (US) | 2004-01-22 | — | — | WO | disclosed |
| US-20030225106-A1 | Substituted alkylamine derivatives and methods of use | AMGEN INC. | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249837-A1 | Process for the Preparation of Pyridine Derivatives | CBR1, CBR3, CCNT1 | KDR 854/4885RXFP1 2513/4885ABCB1 4460/4885 |
| US-20030225106-A1 | Substituted alkylamine derivatives and methods of use | NAT1, PIGO, AADAC | KDR 15/4885RXFP1 1565/4885ABCB1 237/4885 |
| US-20050261313-A1 | Substituted alkylamine derivatives and methods of use | NAT1, PIGO, AADAC | KDR 15/4885RXFP1 1565/4885ABCB1 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.