Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.59 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.59 |
| ▸ | CDK1 | P06493 | 4/20 | 0.59 |
| ▸ | GSK3B | P49841 | 3/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.59 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.59 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.59 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.59 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134607 | 0.92 | CDK2 (0.59) | CDK2CCNA2CCNA1MAPK1CDK1 | |
| SCHEMBL2925638 | 0.90 | CDK2 (0.57) | CDK2CCNA2CCNA1MAPK1CDK1 | |
| SCHEMBL2922937 | 0.88 | CDK2 (0.77) | CDK2CCNA2CCNA1MAPK1CDK1 | |
| SCHEMBL2921851 | 0.86 | CDK2 (0.77) | CDK2CCNA2CCNA1MAPK1CDK1 | |
| SCHEMBL2924144 | 0.85 | CDK2 (0.54) | CDK2CCNA2CCNA1MAPK1CDK1 | |
| SCHEMBL4238904 | 0.85 | CDK2 (0.58) | CDK2CCNA2CCNA1MAPK1CDK1 | |
| SCHEMBL3140421 | 0.84 | CDK2 (0.42) | CDK2CCNA2CCNA1MAPK1CDK1 | |
| SCHEMBL2925306 | 0.84 | CDK2 (0.79) | CDK2CCNA2CCNA1MAPK1CDK1 | |
| SCHEMBL2924756 | 0.81 | CDK2 (0.66) | CDK2CCNA2CCNA1MAPK1CDK1 | |
| SCHEMBL2922889 | 0.80 | CCNA2 (0.52) | CDK2CCNA2CCNA1MAPK1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320531-B1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-09-08 | — | — | EP | claimed |