Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTP4A3 | O75365 | 2/20 | 0.44 |
| ▸ | PTP4A2 | Q12974 | 1/20 | 0.44 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5209408 | 0.84 | CDC7 (0.41) | CDC7DBF4NPC1RAB9ALMNA | |
| SCHEMBL16664022 | 0.83 | CDC7 (0.39) | CDC7DBF4NPC1ALDH1A1MAPT | |
| SCHEMBL15606102 | 0.81 | PARP10 (0.42) | CDC7DBF4ALDH1A1MAOB | |
| SCHEMBL6804853 | 0.81 | CDC7 (0.62) | CDC7DBF4ALDH1A1 | |
| SCHEMBL2433167 | 0.80 | BRD4 (0.47) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10427034 | 0.74 | PTP4A3 (0.44) | PTP4A3PTP4A2PTP4A1CDC7DBF4 | |
| SCHEMBL18333426 | 0.74 | CDC7 (0.76) | PTP4A3PTP4A2PTP4A1CDC7DBF4 | |
| SCHEMBL1823319 | 0.72 | PTP4A3 (0.45) | PTP4A3PTP4A2PTP4A1CDC7DBF4 | |
| SCHEMBL3138935 | 0.69 | MEN1 (0.33) | RAB9AALDH1A1KMT2ACYP2A6MAOA | |
| SCHEMBL17807500 | 0.69 | MAPK10 (0.42) | PTP4A3PTP4A2PTP4A1CDC7DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546410-B2 | Heteroaryl-fused macrocyclic pyrimidine derivatives | ABBVIE INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20100004256-A1 | HETEROARYL-FUSED MACROCYCLIC PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004256-A1 | HETEROARYL-FUSED MACROCYCLIC PYRIMIDINE DERIVATIVES | CDK2, DPYD, CCNB1 | PTP4A3 3275/4885PTP4A2 2830/4885PTP4A1 2558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.