Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 15/20 | 0.42 |
| ▸ | JAK2 | O60674 | 14/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3148900 | 0.92 | AURKA (0.54) | AURKAAURKBJAK3JAK2FYN | |
| SCHEMBL3148163 | 0.86 | AURKA (0.54) | AURKAAURKBJAK3JAK2FYN | |
| SCHEMBL3260561 | 0.82 | AURKA (0.54) | AURKAAURKBJAK3JAK2FYN | |
| SCHEMBL3260565 | 0.82 | AURKA (0.54) | AURKAAURKBJAK3JAK2FYN | |
| SCHEMBL3147289 | 0.81 | AURKA (0.59) | AURKAAURKBJAK3JAK2FYN | |
| SCHEMBL13478839 | 0.80 | AURKA (0.50) | AURKAAURKBJAK3JAK2LCK | |
| SCHEMBL3149215 | 0.80 | AURKA (0.59) | AURKAAURKBJAK3JAK2FYN | |
| SCHEMBL3144184 | 0.80 | JAK2 (0.59) | JAK3JAK2 | |
| SCHEMBL13666766 | 0.79 | AURKA (0.54) | AURKAAURKBJAK3JAK2FYN | |
| SCHEMBL3139607 | 0.79 | AURKA (0.62) | AURKAAURKBJAK3JAK2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511742-B1 | KINASE INHIBITORS | CYTOPIA RES PTY LTD (AU) | 2010-02-03 | — | — | EP | disclosed |