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SCHEMBL31406751

SCHEMBL31406751

Cc1ccc2c(Nc3ccc(Cl)c(CN(C)C)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ BRAF P15056 13/20 1.00
▸ RAF1 P04049 11/20 1.00
▸ CSF1R P07333 11/20 0.76
▸ DDR2 Q16832 6/20 0.76
▸ DDR1 Q08345 5/20 0.76
▸ ARAF P10398 1/20 0.65
▸ ERN1 O75460 1/20 0.43
▸ CYP2C9 P11712 1/20 0.42
▸ FGFR1 P11362 1/20 0.35
▸ KDR P35968 1/20 0.35
▸ TEK Q02763 1/20 0.35
▸ MELK Q14680 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15066293 1.00 BRAF (1.00) BRAFRAF1CSF1RDDR2DDR1
SCHEMBL15067447 0.93 BRAF (0.86) BRAFRAF1CSF1RDDR2DDR1
SCHEMBL15088295 0.93 BRAF (0.86) BRAFRAF1CSF1RDDR2DDR1
SCHEMBL15067504 0.92 BRAF (0.85) BRAFRAF1CSF1RDDR2DDR1
SCHEMBL15067503 0.91 BRAF (0.83) BRAFRAF1CSF1RDDR2DDR1
SCHEMBL15067346 0.90 BRAF (0.87) BRAFRAF1CSF1RDDR2DDR1
SCHEMBL17166449 0.89 BRAF (0.83) BRAFRAF1CSF1RDDR2DDR1
SCHEMBL15066362 0.88 BRAF (0.79) BRAFRAF1CSF1RDDR2DDR1
SCHEMBL15066068 0.88 BRAF (0.88) BRAFRAF1CSF1RDDR2DDR1
SCHEMBL15066228 0.88 BRAF (0.80) BRAFRAF1CSF1RDDR2DDR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3617213-B1 THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES HANMI PHARMACEUTICAL CO LTD (KR) 2025-02-19 — — EP disclosed