Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.70 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.70 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.70 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.70 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.70 |
| ▸ | BRAF | P15056 | 4/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.56 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3142125 | 0.91 | PIK3CA (0.75) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3150673 | 0.89 | PIK3CA (0.67) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3150932 | 0.87 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3141708 | 0.87 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3142679 | 0.85 | PIK3CA (0.78) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3142827 | 0.84 | PIK3CA (0.71) | PIK3CA | |
| SCHEMBL3140790 | 0.84 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3142007 | 0.83 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3137784 | 0.83 | PIK3CA (0.69) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 | |
| SCHEMBL3150136 | 0.81 | PIK3CA (0.67) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075965-A1 | PI3 KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG | 2010-03-25 | — | — | US | disclosed |
| US-20100075965-A1 | PI3 KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075965-A1 | PI3 KINASE INHIBITORS AND METHODS OF THEIR USE | PIK3CA, PIK3CD, PIK3CB | PIK3CA 1/4885PIK3CD 2/4885PIK3CB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.