Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2327914 | 0.91 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DDNMT3A | |
| SCHEMBL2324492 | 0.90 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2323746 | 0.88 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DDNMT3A | |
| SCHEMBL2330721 | 0.88 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DDNMT3A | |
| SCHEMBL2324903 | 0.88 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DDNMT3A | |
| SCHEMBL2328202 | 0.88 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DDNMT3A | |
| SCHEMBL2330938 | 0.87 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DDNMT3A | |
| SCHEMBL2324681 | 0.87 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2325235 | 0.87 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DDNMT3A | |
| SCHEMBL2321036 | 0.87 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DDNMT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010055083-A1 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PD4 INHIBITORS | NYCOMED GMBH (DE) | 2010-05-20 | — | — | WO | disclosed |