Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.51 |
| ▸ | CLPP | Q16740 | 1/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141564 | 1.00 | GRM5 (0.51) | GRM5CLPPPDE2AKMT2AMEN1 | |
| SCHEMBL3133574 | 0.92 | GRM5 (0.59) | GRM5CLPPKMT2AMEN1ATM | |
| SCHEMBL3133581 | 0.92 | GRM5 (0.59) | GRM5CLPPKMT2AMEN1ATM | |
| SCHEMBL3141649 | 0.88 | GRM5 (0.56) | GRM5CLPPKMT2AMEN1ATM | |
| SCHEMBL3141641 | 0.88 | GRM5 (0.56) | GRM5CLPPKMT2AMEN1ATM | |
| SCHEMBL4226969 | 0.84 | GRM5 (0.58) | GRM5CLPPPDE2AKMT2AMEN1 | |
| SCHEMBL4226976 | 0.84 | GRM5 (0.58) | GRM5CLPPPDE2AKMT2AMEN1 | |
| SCHEMBL3132075 | 0.83 | GRM5 (0.61) | GRM5CLPPKMT2AMEN1ATM | |
| SCHEMBL3132085 | 0.83 | GRM5 (0.61) | GRM5CLPPKMT2AMEN1ATM | |
| SCHEMBL4236998 | 0.80 | GRM5 (0.51) | GRM5CLPPPDE2AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004284-A1 | Novel Heterocyclic Compounds as Positive Allosteric Modulators of Metabotropic Glutamate Receptors | ADDEX PHARMA SA (CH) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004284-A1 | Novel Heterocyclic Compounds as Positive Allosteric Modulators of Metabotropic Glutamate Receptors | GRM5, GRM1, GRIK5 | GRM5 1/4885CLPP 4732/4885PDE2A 1249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.