Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13414014 | 0.93 | AGPAT2 (0.43) | ABCG2ABCB1ABCC1PIK3CAAGPAT2 | |
| SCHEMBL3136305 | 0.89 | ABCG2 (0.42) | ABCG2ABCB1ABCC1AGPAT2SCN9A | |
| SCHEMBL3145409 | 0.85 | ABCG2 (0.42) | ABCG2ABCB1AGPAT2SCN9AKCNH2 | |
| SCHEMBL3123801 | 0.84 | MEN1 (0.46) | ABCG2AGPAT2SCN9AKCNH2SCN5A | |
| SCHEMBL3146264 | 0.84 | DYRK1A (0.43) | ABCG2AGPAT2SCN9AKCNH2SCN5A | |
| SCHEMBL3146273 | 0.83 | USP2 (0.38) | ABCG2AGPAT2SCN9AKCNH2SCN5A | |
| SCHEMBL13414016 | 0.83 | AGPAT2 (0.42) | ABCG2ABCB1ABCC1AGPAT2SCN9A | |
| SCHEMBL1644554 | 0.83 | AGPAT2 (0.55) | ABCG2ABCB1AGPAT2SCN9AKCNH2 | |
| SCHEMBL3115406 | 0.83 | AGPAT2 (0.43) | ABCG2AGPAT2SCN9AKCNH2SCN5A | |
| SCHEMBL3112996 | 0.83 | AGPAT2 (0.43) | ABCG2AGPAT2SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075967-A1 | PYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2010-03-25 | — | — | US | disclosed |
| US-7582645-B2 | Pyrimidine derivatives for treatment of hyperproliferative disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2009-09-01 | — | — | US | disclosed |
| US-20070117817-A1 | 4-{3-[(2-Amino-6-phenylpyrimidin-4-yl)amino]phenoxy}-N-methylpyridine-2-carboxamide;anticarcinogenic agents; breast cancer; antitumor agents; respiratory system disorders; urogenital disorders; gastrointestinal disorders; skin disorders; glandular disorders; lymphomas; leukemia; cytolysis | BAYER PHARMACEUTICALS CORPORATION (US) | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075967-A1 | PYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS | TYMP, DPYD, CCNA2 | ABCG2 719/4885ABCB1 1923/4885ABCC1 1807/4885 |
| US-20070117817-A1 | 4-{3-[(2-Amino-6-phenylpyrimidin-4-yl)amino]phenoxy}-N-methylpyridine-2-carboxamide;anticarcinogenic agents; breast cancer; antitumor agents; respiratory system disorders; urogenital disorders; gastrointestinal disorders; skin disorders; glandular disorders; lymphomas; leukemia; cytolysis | CCNA2, MALT1, TPD52L2 | ABCG2 1068/4885ABCB1 2155/4885ABCC1 2184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.