Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4246212 | 0.99 | DPP4 (0.45) | DPP4DPP8NQO2MTNR1AMTNR1B | |
| SCHEMBL3158495 | 0.87 | DPP8 (0.47) | DPP4DPP8MTNR1AMTNR1BMAPT | |
| SCHEMBL3149628 | 0.86 | DPP4 (0.45) | DPP4DPP8MTNR1AMTNR1BMAPT | |
| Hydrochloric Acid SCHEMBL4254227 | 0.86 | DPP8 (0.46) | DPP4DPP8MTNR1AMTNR1BMAPT | |
| Hydrochloric Acid SCHEMBL4244597 | 0.85 | DPP4 (0.44) | DPP4DPP8MTNR1AMTNR1BMAPT | |
| SCHEMBL3144330 | 0.84 | DPP4 (0.49) | DPP4DPP8NQO2MTNR1AMTNR1B | |
| SCHEMBL3155041 | 0.84 | DPP4 (0.49) | DPP4DPP8NQO2MTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL4248376 | 0.83 | DPP4 (0.48) | DPP4DPP8NQO2MTNR1AMTNR1B | |
| SCHEMBL3163056 | 0.83 | DPP4 (0.45) | DPP4DPP8MAPTNPSR1HPGD | |
| SCHEMBL3162664 | 0.83 | KMT2A (0.47) | DPP4DPP8MTNR1AMTNR1BNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| WO-2009066041-A2 | DERIVATIVES OF 1,2,4,5-TETRAHYDRO-3H-BENZAZEPINES, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2009-05-28 | — | — | WO | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |