Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 20/20 | 1.00 |
| ▸ | CHRNA1 | P02708 | 6/20 | 1.00 |
| ▸ | CHRNG | P07510 | 6/20 | 1.00 |
| ▸ | CHRNB1 | P11230 | 6/20 | 1.00 |
| ▸ | CHRNB2 | P17787 | 6/20 | 1.00 |
| ▸ | CHRNB4 | P30926 | 6/20 | 1.00 |
| ▸ | CHRNA3 | P32297 | 6/20 | 1.00 |
| ▸ | CHRNA4 | P43681 | 6/20 | 1.00 |
| ▸ | CHRND | Q07001 | 6/20 | 1.00 |
| ▸ | HTR3A | P46098 | 5/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1956737 | 1.00 | CHRNA7 (1.00) | CHRNA7CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL3143072 | 1.00 | CHRNA7 (1.00) | CHRNA7CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL1459633 | 0.81 | CHRNA7 (1.00) | CHRNA7CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL3152735 | 0.80 | CHRNA7 (1.00) | CHRNA7CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL3152748 | 0.80 | CHRNA7 (1.00) | CHRNA7CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL1956481 | 0.80 | CHRNA7 (1.00) | CHRNA7CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL3149673 | 0.79 | CHRNA7 (0.78) | CHRNA7CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL3150145 | 0.79 | CHRNA7 (0.78) | CHRNA7CHRNA1CHRNGCHRNB1CHRNB2 | |
| Hydrochloric Acid SCHEMBL3154761 | 0.79 | CHRNA7 (0.98) | CHRNA7CHRNA1CHRNGCHRNB1CHRNB2 | |
| Hydrochloric Acid SCHEMBL3154747 | 0.79 | CHRNA7 (0.98) | CHRNA7CHRNA1CHRNGCHRNB1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753719-B1 | SUBSTITUTED PYRROLIDINE-2-ONES | NOVARTIS AG (CH) | 2010-03-03 | — | — | EP | claimed |
| US-20070172421-A1 | Substituted pyrrolidine-2-ones | NOVARTIS AG (CH) | 2007-07-26 | — | — | US | claimed |
| EP-1753719-A1 | SUBSTITUTED PYRROLIDINE-2-ONES | Novartis AG (CH) | 2007-02-21 | — | — | EP | claimed |
| WO-2005118535-A1 | SUBSTITUTED PYRROLIDINE-2-ONES | NOVARTIS AG (CH) | 2005-12-15 | — | — | WO | claimed |
| US-20100125063-A1 | COMBINATIONS OF NICOTINIC ACETYLCHOLINE ALPHA 7 RECEPTOR AGONISTS | NOVARTIS AG | 2010-05-20 | — | — | US | disclosed |
| US-20100125063-A1 | COMBINATIONS OF NICOTINIC ACETYLCHOLINE ALPHA 7 RECEPTOR AGONISTS | NOVARTIS AG | 2010-05-20 | — | — | US | disclosed |
| EP-1753719-B1 | SUBSTITUTED PYRROLIDINE-2-ONES | NOVARTIS AG (CH) | 2010-03-03 | — | — | EP | disclosed |
| US-20080306081-A1 | Combinations of Nicotinic Acetylcholine Alpha 7 Receptor Antagonists | NOVARTIS AG (CH) | 2008-12-11 | — | — | US | disclosed |
| US-20080306081-A1 | Combinations of Nicotinic Acetylcholine Alpha 7 Receptor Antagonists | NOVARTIS AG (CH) | 2008-12-11 | — | — | US | disclosed |
| US-20070172421-A1 | Substituted pyrrolidine-2-ones | NOVARTIS AG (CH) | 2007-07-26 | — | — | US | disclosed |
| EP-1753719-A1 | SUBSTITUTED PYRROLIDINE-2-ONES | Novartis AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005118535-A1 | SUBSTITUTED PYRROLIDINE-2-ONES | NOVARTIS AG (CH) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100125063-A1 | COMBINATIONS OF NICOTINIC ACETYLCHOLINE ALPHA 7 RECEPTOR AGONISTS | CHRNA7, CHRNA4, CHRNA10 | CHRNA7 1/4885CHRNA1 7/4885CHRNG 16/4885 |
| US-20080306081-A1 | Combinations of Nicotinic Acetylcholine Alpha 7 Receptor Antagonists | CHRNA7, CHRNA4, CHRNA10 | CHRNA7 1/4885CHRNA1 7/4885CHRNG 16/4885 |
| US-20070172421-A1 | Substituted pyrrolidine-2-ones | PRLHR, EPOR, FLT1 | CHRNA7 2832/4885CHRNA1 2213/4885CHRNG 2855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.