Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 3/20 | 0.53 |
| ▸ | NQO2 | P16083 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536211 | 0.93 | NQO2 (0.49) | CFTRNQO2KDM4EALDH1A1GAA | |
| SCHEMBL30064505 | 0.93 | NQO2 (0.49) | CFTRNQO2KDM4EALDH1A1GAA | |
| SCHEMBL24918216 | 0.86 | CFTR (0.60) | CFTRNQO2KDM4EALDH1A1GAA | |
| SCHEMBL24413993 | 0.85 | CFTR (0.58) | CFTRNQO2KDM4EALDH1A1GAA | |
| SCHEMBL7896855 | 0.85 | KDM4E (0.52) | CFTRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL15133527 | 0.84 | KDM4E (0.59) | CFTRKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL8380009 | 0.84 | SOS1 (0.50) | CFTRNQO2KDM4EALDH1A1GAA | |
| SCHEMBL31431621 | 0.81 | CA1 (0.44) | CFTRKDM4EGAASOS1TSHR | |
| SCHEMBL6628346 | 0.81 | SOS1 (0.44) | CFTRNQO2KDM4EALDH1A1GAA | |
| SCHEMBL3970865 | 0.81 | CFTR (0.54) | CFTRNQO2KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049326-A1 | TRICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | BIOCRYST PHARMACEUTICALS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |