Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.38 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17513100 | 0.89 | NPSR1 (0.48) | KDM4EL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL3648082 | 0.81 | KDM4E (0.48) | KDM4EL3MBTL1MAPK1SMN1; SMN2TSHR | |
| SCHEMBL28569322 | 0.81 | KDM4E (0.53) | KDM4EL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL5747714 | 0.80 | NPSR1 (0.50) | KDM4EL3MBTL1NPSR1SMN1; SMN2TSHR | |
| SCHEMBL31431734 | 0.80 | CNR2 (0.41) | L3MBTL1NPSR1SMN1; SMN2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL28367308 | 0.80 | KDM4E (0.46) | KDM4EL3MBTL1MAPK1SMN1; SMN2TSHR | |
| SCHEMBL23530235 | 0.79 | KDM4E (0.47) | KDM4EL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL29110028 | 0.79 | KDM4E (0.44) | KDM4EL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL31421969 | 0.79 | NPSR1 (0.48) | KDM4EL3MBTL1NPSR1SMN1; SMN2TSHR | |
| SCHEMBL16030718 | 0.79 | NPSR1 (0.48) | KDM4EL3MBTL1NPSR1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049326-A1 | TRICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | BIOCRYST PHARMACEUTICALS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |