Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 7/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31435926 | 0.92 | PTPN11 (0.43) | PTPN11KCNH2CYP3A4DRD2SLC6A2 | |
| SCHEMBL31435963 | 0.92 | PTPN11 (0.43) | PTPN11KCNH2CYP3A4DRD2SLC6A2 | |
| SCHEMBL31435930 | 0.92 | PTPN11 (0.43) | PTPN11KCNH2CYP3A4DRD2SLC6A2 | |
| SCHEMBL31435955 | 0.91 | PTPN11 (0.42) | PTPN11KCNH2CYP3A4DRD2SLC6A2 | |
| SCHEMBL31435970 | 0.89 | PTPN11 (0.43) | PTPN11KCNH2CYP3A4DRD2SLC6A2 | |
| SCHEMBL31435949 | 0.87 | PTPN11 (0.43) | PTPN11KCNH2CYP3A4DRD2SLC6A2 | |
| SCHEMBL31435901 | 0.87 | PTPN11 (0.46) | PTPN11KCNH2CYP3A4DRD2SLC6A2 | |
| SCHEMBL31435960 | 0.86 | PTPN11 (0.41) | PTPN11CYP3A4DRD2SLC6A2HTR2A | |
| SCHEMBL31435899 | 0.85 | KCNH2 (0.45) | PTPN11KCNH2CYP3A4DRD2SLC6A2 | |
| SCHEMBL31435954 | 0.83 | PTPN11 (0.43) | PTPN11KCNH2MTORKRASPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250019378-A1 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES AS TYRO3 INHIBITORS | HALIA THERAPEUTICS INC (US) | 2025-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250019378-A1 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES AS TYRO3 INHIBITORS | TYRO3, TH, TYR | PTPN11 65/4885KCNH2 3473/4885CYP3A4 776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.