Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.45 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4346342 | 0.94 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR | |
| SCHEMBL4342095 | 0.93 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR | |
| SCHEMBL3803471 | 0.92 | PIK3CD (0.57) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR | |
| SCHEMBL2280427 | 0.88 | PIK3CD (0.53) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR | |
| SCHEMBL189191 | 0.87 | PIK3CG (0.58) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR | |
| SCHEMBL4459861 | 0.83 | PIK3CG (0.53) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR | |
| SCHEMBL18324098 | 0.83 | PIK3CG (0.52) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR | |
| SCHEMBL12373147 | 0.83 | PIK3CG (0.52) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR | |
| SCHEMBL4459854 | 0.83 | PIK3CD (0.57) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR | |
| SCHEMBL4540214 | 0.83 | PIK3CG (0.52) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075947-A1 | Methods of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075947-A1 | Methods of Using PI3K and MEK Modulators | PIK3CA, PIK3CD, PIK3R1 | PIK3CD 2/4885PIK3CG 5/4885PIK3CA 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.